Microsatellite Polymorphism in the Heme Oxygenase-1 Gene Promoter Is Associated with Susceptibility to Cerebral Malaria in Myanmar
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概要
- 論文の詳細を見る
Cerebral malaria (CM) is a serious complication of Plasmodium falciparum malaria, and its pathogenesis leading to coma remains unknown. Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide. The HO-1 gene promoter contains a polymorphic (GT)n repeat which may influence the expression level of HO-1. To explore the correlation between this (GT)n polymorphism and susceptibility to CM, we analyzed the frequencies of the (GT)n alleles in 120 Myanmarese patients with uncomplicated malaria (UM) and 30 patients with CM. The frequency of homozygotes for the short (GT)n alleles (<28 repeats) in CM patients was significantly higher than those in UM patinets (P < 0.008, OR = 3.14). Thus, short (GT)n alleles represent a genetic risk factor for CM.
- National Institute of Infectious Diseases,国立感染症研究所の論文
著者
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Kikuchi Mihoko
Department Of Immunogenetics Institute Of Tropical Medicine (nekken) Nagasaki University
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UBALEE RATAWAN
Malaria Research Laboratory, Karolinska University Hospital
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