Molecular Characterization and Clinical Evaluation of Dengue Outbreak in 2002 in Bangladesh
スポンサーリンク
概要
- 論文の詳細を見る
During the febrile illness epidemic in Bangladesh in 2002, 58 people died out of the 6,132 affected. Two hundred hospitalized patients were analyzed clinically, serologically and virologically to determine the features of this dengue infection. Among the 10- to 70-year-old age group of the 200 clinically suspected dengue patients, 100 (50%) were confirmed as dengue cases by virus isolation and dengue IgM-capture ELISA. Of the 100 dengue-confirmed cases, the mean age was 29.0 (+/-12.4). The possible dengue secondary infection rate determined by Flavivirus IgG-indirect ELISA was 78% in 2002. Eight dengue virus strains were isolated, representing the first dengue virus isolation in the country, and all of the strains were dengue virus type-3 (DEN-3). Sequence data for the envelope gene of the DEN-3 Bangladeshi isolates were used in a phylogenetic comparison with DEN-3 from other countries. A phylogenetic analysis revealed that all 8 strains of DEN-3 were clustered within a well-supported independent sub-cluster of genotype II and were closely related to the Thai isolates from the 1990s. Therefore, it is likely that the currently circulating DEN-3 viruses entered Bangladesh from neighboring countries.
- National Institute of Infectious Diseases,国立感染症研究所の論文
National Institute of Infectious Diseases,国立感染症研究所 | 論文
- Helicobacter pylori vacuolating cytotoxin, VacA
- The Bactericidal Efficacy of a Photocatalytic TiO2 Particle Mixture with Oxidizer against Staphylococcus aureus
- Molecular Characterization and Clinical Evaluation of Dengue Outbreak in 2002 in Bangladesh
- Microsatellite Polymorphism in the Heme Oxygenase-1 Gene Promoter Is Associated with Susceptibility to Cerebral Malaria in Myanmar
- Dispersal of a Blow Fly, Calliphora nigribarbis, in Relation to the Dissemination of Highly Pathogenic Avian Influenza Virus