定常空気呼吸時の血漿内イオン濃度の解析
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Ionic concentrations in blood plasma depend on [HCO_3^-] and water content [H_2O]. It has been shown previously, that the change in ionic concentration depending [HCO_3^-] has two components, which can be expressed by specific experimental equations through regression analysis. By using these equations in the present work, the two components of [HCO_3^-] were excluded from measured concentrations, and those changes in ionic concentrations, which depend on the change in [H_2O], were analysed. The concentrations in this third components, which are denoted by the prefix 'i', were mainly obtained in plasma from elderly patients, where i[Na^+] was widely distributed and, in addition, i[Cl^-] was linearly related to i[Na^+]. Thus, it was demonstrated that the concentrations in the third component depend on [H_2O]. At the standard state of [HCO_3^-] in normal subjects, the ratio of [Cl^-] to [Na^+] is about 0.738. However, the regression coefficient of i[Cl^-] against i[Na^+] was about 0.77. This result suggested that to maintain electroneutrality a NaCl shift occurs across the capillaries together with a water shift, depending on the change in [H_2O] in interstitial fluid. Using the regression coefficient, the difference between the [H_2O]-dependent components of [Na^+] ([Na^+]) and of [Cl^-] ([Cl^-]) was obtained, and [H_2O] in plasma was estimated from [Na^+]-[Cl^-]. Furthermore, i[K^+] was linearly related to [Na^+]-[Cl^-] and from the regression function the shift of K^+ across the RBC membrane could be estimated. It also became clear that the imbalance between i[Na^+] and i[Cl^-] was compensated by the change in concentration of other strong ions, i.e. the change in anion gap. Keywords: Osmotic pressure, Interstitial fluid, Water shift, Electroneutrality, Exogenous ions
- 山形大学の論文
- 2006-02-15
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