定常空気呼吸時の血漿内pH,重炭酸イオン濃度及びCO_2分圧の代謝性変化の解析

概要

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Previously we analysed [HCO3-] in blood plasma, by dividing it into a respiratory component, [HCO3-]*, and a metabolic component, [HCO3-]o. Assuming [HCO3-]o to be independent of Pco2, an exponential function of Pco2 was obtained for [HCO3-]*. More recently, we found, through regression analysis of the difference in pH from 7.4, that the metabolic component of pH-7.4, designated by pH-pH*, could be evaluated by using the ratio [HCO3-]o/[HCO3-]*, and that this ratio, not the value for [HCO3-]o, was independent of Pco2. [HCO3-]o at pH = 7.4, designated by s[HCO3-]o, was calculated to test the validity of [HCO3-]*, the regression functions of [HCO3-]o and s[HCO3-]o in venous blood, against those in arterial blood, were then calculated. Both the correlation and regression coefficients were close to unity, though the regression coefficient of^n [HCO3-]o was slightly higher than that of s[HCO3-]o. Further, in arterial and venous blood, the regression lines of pH and Pco2 against s[HCO3-]o were obtained in a number of acidotic and alkalotic patients, and the change in Pco2, compensating for pH, was quantified. Designating [H+] in normal blood, where s[HCO3-]o = 0, by [H+]*, the ratio [H+]/[H+]* was obtained in a number of anemic patients to check the effect of the hemoglobin concentration [Hb] on the metabolic change in pH. [H+] agreed well with [H+]*, and no significant effect of [Hb] on the metabolic change in pH was found.
山形大学の論文
2007-08-15