高張果糖溶液皮下注射による廿日鼠肉腫の発生実験

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Following the experiments of daily subcutaneous injections of 25 g/dl laevulose solutions in dosis of 0.5 cc into mice, we obtained results as follows. 1) We found 9 sarcomas in 39 mice (23%), which were living above 250 days. Histologically they were made up of fibrosarcoma 6, spindle celled sarcoma 2, reticulosarcoma 1. They were successfully homotransplanted. Concerning important factors of the origin of the mouse sarcoma, we found that 25-1.14006/dl laevulose solution demonstrated later than 5 7.36439e+223/dl laevulose solution into the liver in the capacity of Glycogen by the subcutaneous injection, and remained longer in the subcutaneous connective tissue of injected area, simulated mitotic figure and special multiplications. 2) We found 9 amyloidosis in 39 mice (41%), which were living above 250 days. We observed on the mice, which died due to amyloidosis, no multiplications of the subcutaneous connective tissue, and no trace of sarcoma. Subcutaneous fibroblastcelle granulies in the sarcoma growing-mice were of small diffuse multiplications shape, but on the amyloid-mice they were of irregular shape, large or small. 3) It seemed, the growth of laevulose sarcoma was not sudden, but gradual. 4) We could not find inflammations occur in sarcoma-growth throughout. 5) Growth and enlargement of the transplanted laevulose sarcoma were in direct proportion to the multiplications of myeloidcells in the haematopoetic organs. (Author's abstract)
千葉医学会の論文

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杉下正孝
千葉大学第1病理

高張果糖溶液皮下注射による廿日鼠肉腫の発生実験

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