Parabenzochinonによる甘日鼠皮膚癌及び肺臓癌の発生実験
スポンサーリンク
概要
- 論文の詳細を見る
Following daily cutaneous applications of 0.2 0xbfed16c0arabenzoquinone 2-3 cc, reduced (sufficiently light) and nonreduced (light shutter fully) by Tsutsui's method on mice, we attained results as follows. 1) The 28 mice above lived 100 days. We had 1 skin-cancer and 6 papillomas (25%), 3 lung-cancers, 7 high special multiplications and 4 middle special multiplications in their lung tissue (21%), by reduced quinone; 1 skin-cancer and 2 papillare special multiplications in their skin tissue (21%), 1 lung-cancer, 2 high special multiplications and 4 middle special multiplications in their lung tissue (50%). by nonreduced quinone. The mice with skin-cancer or papillare special multiplications on their skin tissue, usually confirmed lung-cancer or special multiplications in their lung tissue, sometimes atypical multiplications in their liver. Histologically they were made up of platte celled or spindle celled-cancer on their skin tissue, and of papillary adeno-cancer in their lung tissue. It seems the ferment poison-theory has taken an important part in the origin of quinone-cancer. 2) Growth of the lung and skin-cancer produced by quinone was not spontaneous, but gradual. We scarcely found any inflammation through all the course of quinone-cancer. 3) We had homo-subcutaneous and intraperitoneal grafts of the transplantable quinone-cancer of mouse. They showed the positive results above in about 70%; and we found the cancerogenic peritonitis with blood in great numbers of mice bearing intraperitoneal grafts. Furthermore we could make easily artificial cancer by pouring such intraperitoneal tumor-exudate into selected parts of other mice. We had successfully 6 generations on the case of the most good results in the homotransplantation by intraperitoneal tumor-exudate, and tendency to decrease tumor-exudate and to form tumor-nodulies; but by transplanting an intraperitoneal grafts to other mice with a piece of tumor tissue, we succeeded easily in producing again the cancerogenic peritonitis with blood. The homotranspl
- 千葉医学会の論文
著者
関連論文
- 14.肺に於ける気道の異型増殖,初期癌,早期癌に就て(第383回千葉医学会例会)
- Parabenzochinonによる廿日鼠皮膚癌及び肺臓癌の発生実験
- Parabenzochinonによる甘日鼠皮膚癌及び肺臓癌の発生実験
- 高張果糖溶液皮下注射による廿日鼠肉腫の発生実験