A possible association of single-nucleotide polymorphisms in the alpha-helix coiled-coil rod homologue gene with psoriasis in a japanese population

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The α-helix coiled-coil rod homologue (HCR) gene is known to be associated with the susceptibility of various races to psoriasis vulgaris (PV). This study aimed to analyze single-nucleotide polymorphisms (SNPs) in HCR in Japanese PV patients and investigate the association between these SNPs and PV in the Japanese population. The PV group comprised 75 PV patients from our hospital; the control group, 75 healthy individuals. By using the direct sequencing method, we analyzed SNPs in HCR at exons 4, 13／14, and 18, genetic polymorphisms in which are associated with susceptibility to PV in Caucasian and Taiwanese populations. We then investigated the association between these SNPs and PV. The association between PV and HCR -404^*T, HCR-1802^*T, and HCR-2406^*T was statistically significant. Other SNPs were not statistically significant at 5％ level. Compared with the previous study in Finnish and Taiwanese populations, in our study, the frequencies of SNPs at the risk alleles were lower in both PV patients and healthy controls. HCR-2406^*G showed the most frequent SNPs (17.3％ vs 4.0％ in controls; odds ratio ＝ 5.03, 95％ confidence interval ＝ 1.37-18.5; p ＝ 0.015). These observations suggest that HCR may be a candidate gene for susceptibility to PV in the Japanese population.
Yamaguchi University School of Medicineの論文