The immunomodulator FTY720 is phosphorylated and released from platelets
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概要
- 論文の詳細を見る
The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues. In vivo, FTY720 is phosphorylated to FTY720-P, which binds to the sphingosine 1-phosphate receptor S1P1. So far, it has been unclear where FTY720-P is produced. We demonstrate that platelets efficiently convert FTY720 to FTY720-P and release it into the extracellular space. This release is mostly independent of platelet activation, but is slightly increased upon thrombin stimulation. These results suggest that platelets are a major source of plasma FTY720-P, and that FTY720-P release is mediated by two different transporters.
- Elsevier B.V.の論文
- 2007-07-30
著者
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Igarashi Yasuyuki
北海道大学 大学院生命科学院生体機能化学研究室
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Igarashi Yasuyuki
Department Of Biomembrane And Biofuntional Chemistry Graduate School Of Pharmaceutical Sciences Hokk
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