トキソプラズマ症の血清学的診断法及び長崎市における疫学的検討

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We studied the sensitivity and speciality of indirect hemagglutination test (IHA test) in serological diagnosis of toxoplasmosis by means of dye test which was the standard method. IHA test (HA-KW: KYOWA, Co) was commercially available in Japan. We measured 190 serum specimens with IHA titer and dye test (Fig. 1, Fig. 2). Coincidence rate was 89.5% and in uncoincident specimens (dye test(+), IHA test(-)) were 95%. And we found that IHA test was inferior to dye test and that there is a tendency to overlook the positive cases which have low titer. However, IHA test was more useful than dye test in clinical examination. We examined 2046 cases in Nagasaki city with IHA test since 1978 to 1981. Positive rate of pregnant women in Nagasaki city was 122/1893=6.4%. And it was suspected that about 0.2% of pregnant women were newly infected with toxoplasmosis every year. We investigated the transition of IHA titer in 77 cases on 180 specimens in the passage of time. Four cases gave transition more than 4 times, but in pair re-examination all cases gave transition within 4 times. We compaired IHA positive rate in various objects. Healthy pregnant women: 136/1936=7.0%, pregnant women having history of abnormal delivery: 6/37=16.2%, ophthalmologic patients: 11/34=32.4%, patients of end stage: 4/17=24.0%, lymphadenitis: 3/3=100%.
長崎大学熱帯医学研究所,Institute of Tropical Medicine, Nagasaki Universityの論文
1983-06-30