風疹生ワクチンの試験接種とその効果

概要

論文の詳細を見る
One hundred and eighty unmarried young women were examined for rubella hemagglutination-inhibition (HI) antibody in their sera and then administerd subcutaneously with live attenuated rubella virus vaccine (Kaketsuken, Lot 6-2, GMK_3, SK_<60>, RK_6). Twenty-three (13%) of 180 individuals were seronegative for rubella HI antibody. When these susceptible subjects were immunized with single injection of the vaccine, all individuals manifested high levels of HI antibody response 6 weeks later. The remaining one hundred and fifty-seven individuals who were seropositive were also injected with the vaccine. The results indicated that in 70% of these individuals, HI antibody titers increased more than 2 times of the original titers and that the antibody response was higher in those whose original antibody titers were lower levels. Slight clinical reactions such as swelling of lymphnode and joint pain were observed only in 4 cases, but these cases were all from those who had possessed the antibody at the time of vaccination. No virus was recovered from the pharyngeal swabs which were collected from vaccine recipients on day 7, 11, 13 and 15 after administration of the vaccine.
長崎大学熱帯医学研究所,Institute of Tropical Medicine, Nagasaki Universityの論文
1975-03-20