オンコセルカ症に於るDietnylcarbamazineの末梢血液像に与える影響

概要

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オンコセル症の治療目的でDiethylcarbamazine(DEC)を経口投与した時の末梢血液像の変化を32名の患者について観察した.DECの投与により総白血球は有意に上昇し,その原因は血球分画における好中球の増加によるものと考えられる.好酸球,リンパ球の変動に有意差はみられなかった.仔虫密度のDEC投与時における末梢血液像に与える影響はあまりみられなかった.The change of blood picture at the 3rd day of Diethylcarbamazine (DEC) administration was studied in thirty-two Guatemalan patients with onchocerciasis. They were administered DEC tablets dialy seven consecutive days at the dosage of 5mg/kg body weigth. The increase of total white blood cell counts was statistically significant between before and the day 3 of administration. The increase of total white blood cell counts was due to that of nuetrophil counts. The changes of eosinophil and lymphocyte counts were not statistically significant. The relation between the change of blood picture and the number of microfilariae in the skin snip was not seen.
長崎大学熱帯医学研究所,Institute of Tropical Medicine, Nagasaki Universityの論文
1983-03-30