Carcinoma of the Rectum Following Irradiation for Cervical Cancer

概要

論文の詳細を見る
In this paper, 4 cases of rectal cancer possibly induced by radiotherapy for cervical cancer are reported, with special reference to radiation-carcinogenesis relationship. For detecting radiation-induced rectal cancer, we reviewed 34,783 cases with tumor or tumor-like lesion registered to the Nagasaki Tumor Registry Committee. As a result, we found 4 cases reported here from 296 female cases of rectal cancer, the rate being 1.35%. The latent period ranged from 10 to 27 years, the mean being 19.5 years. In all of these 4 cases, tumors were located in the anterior wall of the rectum 3-6 cm from the anal verge. Macroscopically, they were Borrmann II-III type. Microscopically, they were well differentiated adenocarcinoma, some of which revealed mucinous carcinoma in parts. The rectal wall of three resected cases showed fibrosis of the submucosa and surrounding tissue, where the blood vessels showed sclerosis and hyalinization, due to previous irradiation.