気道閉塞性肺疾患の換気異常 : Spiral computed tomography (spiral CT) による肺 dynamic densitometry (PDD) とゼノンガス肺 dynamic SPECT による検出
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概要
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PURPOSE: The usefulness of pulmonary dynamic densitometry (PDD) acquired by spiral computed tomography (CT) to detect ventilation abnormalities in obstructive airway disorders was evaluated in comparison with dynamic xenon-133 (Xe-133) SPECT. MATERIALS ANTD METHODS : Eight-second, continuous spiral CT scan was performed over 2-3 respiratory cycles in six healthy volunteers, 19 patients with airways disorder, and six patients with restrictive lung disease. The data set were reconstructed as 36 one-second temporarlly overlapping images at 0.2-second intervals, and regional PDD curves were displayed. Regional ventilation was assessed by Xe-133 clearance-time on Xe-133 SPECT. RESULTS: Normal lungs showed smooth, sinusoidal PDD curves with maximal amplitude in lung attenuation change (MALAC) of 54.9 + 24.5 HU; whereas, obstructive airways disorders with prolonged Xe-133 clearance showed significantly diminished MALAC (31.6 + 20.1 HU, P < 0.0001), accompanied by irregularity, asynchronous phase, and deterioration of normal ventral-to-dorsal gradients in MALAC and lung attenuation. Restrictive diseases without prolonged Xe-133 clearance did not show statistically significant reduction in MALAC. In total 251 lung regions, regional MALAC correlated inversely with Xe-1 J3 clearance-time (r = 842). CONCLUSION: PDD acquired by spiral CT is acceptable for detecting ventilation abnormalities in obstructive airways disorder. (Radiology, 202: 855-862, 1997.)
- 山口大学医学会の論文
- 1999-10-30
著者
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菅 一能
山口大学医学部放射線部
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Matsunaga Naofumi
Department of Radiology,Yamaguchi university Graduate School of Medicine
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菅 一能
山口大学医学部放射線医学講座
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KUME Norihiko
Department of Radiology, Yamaguchi University School of Medicine
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NISHIGAUCHI Kazuya
Department of Radiology, Yamaguchi University School of Medicine
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SHIMIZU Kensaku
Department of Radiology, Yamaguchi University School of Medicine
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Matsunaga Naofumi
Department Of Radiology Yamaguchi University Graduate School Of Medicine
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Kume Norihiko
Department Of Radiology National Cardiovascular Center
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Kume Norihiko
Department Of Radiology Yamaguchi University School Of Medicine
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TAKANA Katsuyuki
Department of Radiology, Yamaguchi University School of Medicine
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KOIKE Shinji
Department of Radiology, Yamaguchi University School of Medicine
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Koike Shinji
Department Of Radiology Yamaguchi University School Of Medicine
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Shimizu Kensaku
Department Of Radiology Yamaguchi University School Of Medicine
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Takana Katsuyuki
Department Of Radiology Yamaguchi University School Of Medicine
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Nishigauchi Kazuya
Department Of Radiology Yamaguchi University School Of Medicine
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菅 一能
聖比留会セントヒル病院放射線科
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