Difference in DNA copy number aberrations detected between Osteosarcoma and Malignant Fibrous Histiocytoma

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Osteosarcoma (OS) and malignant fibrous histiocytoma (MFH) are the most frequent sarcomas of the bones and soft tissues, respectivery. These tumors share a spectrum of histpathologic features. In order to elucidate the similarity and difference of tumor-specific genetic alterations between them, we analyzed DNA copy number aberrations of 7 Oss and 12 MFHs using comparative genomic hybridization (CGH). In OS a DNA copy number gain of chromosome 1p21-pter was the most frequent aberration (85.7%; 6/7 tumors). Furthermore, gains of 6p12-p24, 8q13-q23, and 1q21.1-q25 and losses of 10p, 10q, 16p, 2q31-q36, 3p12-p21.3, 6q, 8p21.1-pter, 9p21-pter, 13q13-q21.1, and 19q13.2-qter werefrequent. In MFH, gains of 5p-12-p22.3, 7p12-p21, 7q, 9q13-q32, 12q13.1-q22.3, 14q11.2-q13, and 15q12-22.3 and losses of 1p31.2-pter, 9p21-pter, 10p, 10p, 19q and 13q were frequently detected. Gains of 1p21-pter, 6p12-p24 and 8q13-q23 were preferentially found in OS. A loss of 1p31.2-pter, gains of 5p13.1-15.3 and 15q11.2-23 were detected exclusively for MFH. These observations suggest that differences in these DNA copy number aberrations between OS and MFH could be an additional aid in the differential diagnosis of two diseases.
Yamaguchi University Graduate School of Medicineの論文