The Mechanism of Alleviation of the Epileptic Seizures Following the Caudal Excitability, Electrolytes and Brain Carbonic Anhydrase
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The effect of subtotal pancreatectomy on brain excitability and its neurochemical mechanisms were studied in mice. The results can be listed as follows : 1. Subtotal pancreatectomy decreased brain excitability in mice, as indicated by an elevation of electroshock seizure threshold and shortening of maximal seizure duration. 2. Subtotal pancreatectomy produced alterations in electrolyte concentration in the brain and serum ; brain calcium concentration tended to increase after 3 weeks and showed a significant increase after 6 weeks, while brain sodium, potassium and chloride did not change. Serum sodium concentration was signincantly increased 6 weeks after pancreatectomy, while serum potassium and chloride concentration were altered only slightly. 3. Subtotal pancreatectomy caused alteration in electrolyte distribution in the brain ; the ratio of extracellular to intracellular sodium concentration, when calculated on the basis of the chloride space as a measure of extracellular fluid volume, was found to be increased, while the ratio of intracellular to extracellular potassium concentration was also found to be increased. 4. Activity of brain carbonic anhydrase was signincantly decreased either 3 weeks or 6 weeks after pancreatectomy. 5. From the discussion in this paper, it may be concluded that the increase in serum sodium or extracellular sodium concentration in the brain following subtotal pancreatectomy is responsible for the elevation of the electroshock seizure threshold, while the decrease in carbonic anhydrase activity in the brain is closely related to the reduction of the maximal seizure duration.
- Yamaguchi University Graduate School of Medicineの論文
Yamaguchi University Graduate School of Medicine | 論文
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