Field-stimulation Can Elicit Membrane Action Potential in Mammalian Myocardium

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The concentrations of cyclic 3', 5' -guanosine monophosphate (cGMP) and cyclic 3', 5' -adenosine monophosphate (cAMP) in the cerebellar and cerebral cortex were measured during lidocaine infusion in rats. The rats were divided into three groups, control, lidocaine (0.74 mg/min) and bicuculline (1.2 mg/kg). The lidocaine group was divided into four stages according to the EEG pattern; desynchronized, seizure and recovery. At the desynchronized and synchronized stages, cGMP and cAMP concentrations in both cerebellar and cerebral contex remained unchanged except for a modest decrease in cerebral cortex at the desynchronized stage. At the seizure stage, cerebellar cGMP increased from 5.2±0.9 to 9.2±1.4 pmols/mg protein and cerebellar cAMP decreased from 8.9±0.6 to 6.9±0.6 pmols/mg protein. These changes in concentrations at the seizure stage returned to the control levels at the recovery stage. With bicuculline, cGMP and cAMP concentrations strikingly increased in both cerebellar and cerebral cortex. These results suggested that the cerebellum contributed to lidocaine-induced seizures.
Yamaguchi University Graduate School of Medicineの論文