Evidence of Calcium Regulation by Mitochondria in Smooth Muscle
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The effects of caffeine on the calcium regulation by mitochondria were studied in connection with the contracture tension of the stomach smooth muscle. Electron microscopic observation showed that the mitochondria in smooth muscle could take up calcium ion when the muscle was soaked in the excess calcium Ringer solution; in such solution intramitochon-drial electron dense precipitates, probably calcium compounds due to either oxalate or pyroantimonate, were increased in the presence of caffeine. Their appearances exhibit electron dense granules, some of them showed annular aggregates. These results strongly suggest that the mitochondria in smooth muscle cell can function to regulate the cytoplasmic ionized calcium. Physiological study showed that no contracture was induced by soaking the muscle in Ringer's solution containing caffeine (1 to 10 mM); prolonged exposure of the muscle to caffeine Ringer caused an appreciable reduction of the contracture tension which was induced by means of either electrical stimulation or potassium-depolarization. It is hypothesized that the reduced tension caused by caffeine would primarily result from the greater accumulations of calcium by the mitochondria which in turn lead to the decrease of intracellular available calcium. Massive accumulation of calcium in the mitochondria might also cause the gradual impairment of the intramitochondrial energy production system.
- Yamaguchi University Graduate School of Medicineの論文
Yamaguchi University Graduate School of Medicine | 論文
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