The Effect of Hyperthermia on Cerebral Energy Metabolism Studied with vivo 31P Nuclear Magnetic Resnance Spectrosccopy
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Energy metabolism in the Wistar rat brain was studied by means of in vivo nuclear magnetic resonance spectroscopy after heating. The 31P-spectra were recorded at 10 minutes after heating the brain to 44 or 45℃ (cortical temperature) for 30 minutes on 6 rats in each group. Thereafter, the 31P-spectra were repeatedly recorded until 1 hour after heating. The 31P-spectra showed no significant changes of pH and high-energy phosphate levels occurred for 1 hour after heating of the brain to 44℃ for 30 minutes. However, those determined 10 minutes after heating the brain to 45℃ for 30 minutes showed a statistically significant reduction of the PCr/Pi ratio without accompaning a pH shift and change in ATP concentration. No further changes occurred thereafter for 1 hour after heating of the brain. The heat-induced PCr/Pi ratio reduction observed in this study reflected mitochondrial dysfunction and not a decline in cerebral blood flow. The present study has demonstrated at least part of the heat-induced damage of the brain occurred at mitochondrial level in vivo, while cerebral enerfy metabolism was found to be preserved up to cortical brain temperature of 44℃.
- Yamaguchi University Graduate School of Medicineの論文
Yamaguchi University Graduate School of Medicine | 論文
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