Studies on Measles Virus in Tissue Culture (II) Electron Microscopic Study of Measles Virus Infected Cells and Localization of Virus Antigen Examined by Ferritin-Conjugated Antibody Method
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The fine structure of inclusion body and morphological changes in VERO cells infected with Edmonston strain of measles virus has been examined in the electron microscope. Localization of virus antigen has been studied by means of feritinconjugated antibody method. And the following results are obtained. 1) The fine structure of the nuclear inclusion material is found to consist mainly of randomly arrayed tubular structures with frequent ordered array. The width of these tubular structures is estimated at 15-20mμ. 2) The cytoplasmic inclusion is also consisted of an aggregate of randomly arrayed tubular material, which has the morphological resemblance to that found in the nuclear inclusion but is wider than that having approximate diameter of 30Mμ. Ordered array of the tubular structure is never revealed in the cytoplasmic inclusion area. 3) Many of the infected cells which contain tubular structure in the cytoplasmic inclusion show the characteristic cytoplasmic processes or spherical forms on and outside the cell wall. The spherical forms might be divided into two groups; one is the small one which has dense internal component and the other is the large one which is devoid of internal structure. Although the small one may be mature viral particle, the larger one on the contrary, could not be estimated as viral particle but as the cytoplasmic fragment though it has the same surface appearance as that of the small one. 4) Measles virus antigen has been demonstrated on the surface of both the small and large spherical particles, and also occasionally on the surface of the host cell.
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Yamaguchi University Graduate School of Medicine | 論文
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