Serum Hepatitis B Antigen Particles in various Liver Diseases : Relation to Immunological Tests for Hepatitis B Antigen

概要

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Immunological detection of HBAg and the electron-microscopic observation of HBAg particles were performed on 196 serum samples collected from a total of 183 cases consisting of 58 of acute hepatitis, 8 of prolonged hepatitis, 60 of chronic hepatitis, 30 of liver cirrhosis, 21 of hepatoma and 6 of fulminant hepatitis, and the results obtained by both techniques were studied comparatively. As the result, the discrepancy between both techniques was noted in 19.9% (35/196) of the total serum samples, and almost all of the discrepancy was seen in the serum samples which were negative for HBAg by radioimmunoassay but exhibitid the particles electron-microscopically. The incidence of HBAg in various liver diseases determined electron-microscopically was recorded at 63.7% (37/58) for acute hepatitis, at 60% (36/60) for chronic hepatitis including 66.6% (26/39) for aggresive form, at 50% (15/30) for liver cirrhosis and at 71.4% (15/21) for hepatoma, and these values were more than 10% higher than those determined by immunological techniques. These results indicated that electron microscopy was a more sensitive method than immunological tests for detecting HBAg and supported the hypothesis that HBAg may play some role in the development of chronic liver disease and hepatoma.
Yamaguchi University Graduate School of Medicineの論文