Effects of Intraventricular Osmotis Pressure on the Formation Rate of Cerebraspinal Fluid and Subsequent Distribution of Electrolytes Between the Fluid and Serum in Rabbits.
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Ventriculocicternal perfusions with artificial CSF were carried out in rabbits. The rate of formation of CSF in the contral animals was found to be 10.9±0.5μl/min. Hypertonic perfusion was performed by adding NaCl or monosaccharides into the perfusion fluid and the osmotic influence these had upon CSF formation was investigated. A remarkable incease in the rate of formation of CSF was observed in the NaCl group, after a steady atate was achieved in the perfusion system, while in the xylose-glucose group, the increase in the rate of formation of CSF was not only less marked but also of shorter duration, despite increased osmolality of the porfusate. In the xylose-glucose group, when the osmotic gradient between porfusate and serum was produced by the addition of sugars to the porfusate, we found that there probably existed a critical ,agnitude of osmotic gradient required in order to initiate osmotic flow through the ependymal linings and/or choroidal epithelium. We estimated this cirtical value to be approximately 30 mOsm/L. Analysis of electrolytes in the effluent revealed no remarkable alteration during perfusion with hyperosmotic slutions when compared with those of the contrals, expect for concentrations of Na+ and Cl- in the NaCl group. The active transport of electrolytes followed by diffusion of water, saturation of a sugar-transport mechanism, and regulation of electrolyte concentration in the ventricular system are all thought to be factors contributing to the homeostatic mechanism which regu;ates the production of CSF.
- Yamaguchi University Graduate School of Medicineの論文
Yamaguchi University Graduate School of Medicine | 論文
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