Pathologic Study on Amyloidosis : Amyloidosis of the Islets of Langerhans in Diabetes Mellitus

概要

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　(1)Amyloidosis of the islets in 222 diabetic pancreas was examined by using various stainings, fluorescent microscope, polarized microscope and electron microscope. In l24 cases (55.8 %), amyloidosis of the islets of Langerhans was found, but hyalinization of the islets was not encountered. (2) Amyloid substance was closely situated at the wall of capillaries in the islets and was adjacent to the capillary endothelial cells. (3) Deposit of amyloid in the islet was divided into four types ; nodular, linear, fascicular, massive type. Nodular type of amyloidosis was most frequently observed. (4) Amyloidosis of the islets of Langerhans showed the tendency to increase with advancing age. (5) It was presumed that secretory mechanism of the islet cells was related to the occurrence of amyloid substance.
Yamaguchi University Graduate School of Medicineの論文