Diazepen Alters Electrical Activities of the Human Spinal Cord

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Cerebral hemodynamic effects of continuous infusion of vasodilating drugs, hydralazine; 10μg/kg/min, nitroprusside: 5μg/kg/min, nitroglycerin; 5μg/kg/min, trimethaphan; 5μg/kg/min, were studied in twenty dogs anesthetized with halothane (0.28% end-tidal). With hydralazine, the mean arterial pressure (MAP) maximally decreased to 88% of the control, and cerebrospinal fluid pressure (CSFP) and cerebral blood flow (CBF) increased to 231% and 180% of the control, respectively. With nitroprusside, MAP maximally decreased to 78% of the control, and CSFP increased to 140% of the control with unchanged CBF. With nitroglycerin, MAP maximally decreased to 87% of the control, and CSFP and CBF increased to 168% and 108% of the control, respectively. With trimethaphan, MAP maximally decreased to 90% of the control, and both CSFP and CBF remained unchanged. It was concluded that vasodilating drugs had differential cerebral hemodynamic effects and there was no consistent relationship between CSFP and CBF during infusion.
Yamaguchi University Graduate School of Medicineの論文