Ultrastructural Study on the Spleens of 28 Patients with ITP：Platelet Phagocytosis of Cordal Macrophages

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概要

• 論文の詳細を見る

• Spleens of 28 patients with idiopatic thrombocytopenic purpura have been observed histologically, immunohistologically and electron microscopically. Spleens of fifteen patients had the foamy cells in the red pulp. Some foamy cells had positive materials for anti-human platelet antibody, using the unlabelled immunoperoxidase method. Electorn microscopically, many platelets in varying stages of intracellular digestion from intact-appearing platelets to myelinlike materials were disclosed in the foamy cells. We suggest that there are two types of the macrophage in the spleen from patients with ITP. One does not reveal foamy cytoplasm, because phagocytized are immediately digested by the lysosomal enzyme within cytoplasm of macrophages. The other has foamy cytoplasm, because phagocytized platelets are incompletely digested and remain as myelinlike materials within cytoplasm of macrophages.

• Yamaguchi University Graduate School of Medicineの論文

著者

• GONDO Toshikazu

  Department of Surgical Pathology, Yamaguchi University Hospital

• Takahashi Mutsuo

  Department Of Surgical Pathology Yamaguchi University Hospital

• ISHIHARA Tokuhiro

  First Department of Pathology, Yamaguchi University School of Medicine

• YOKOTA Tadaaki

  Department of Pathology, Kokura Memorial Hospital

• UCHINO Fumiya

  Yamato Town Hospital

• Yokota Tadaaki

  Department Of Pathology Kokura Memorial Hospital

• Gondo T

  山口大学 医学系研究科泌尿器科学

• Yamashita Y

  Department Of Pathology Tokuyama Central Hospital

• Takahashi Masayo

  Department Of Ophthalmology And Visual Sciences Graduate School Of Medicine Kyoto University

• Ishihara Tokuhiro

  First Department Of Pathology Yamaguchi University School Of Medicine

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