Induction to Granulocytic Differentiation of Human Promyelocytic Leukemia Cells （HL－6０） by Polyprenoic Acid （E5166）
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概要
- 論文の詳細を見る
The effects of synthesized polyprenoic acid, E5166,on human promyelocytic leukemia cell line, HL60, were examined. The cells continuously exposed to the drug in vitro underwent growth inhibition and granulocytic differentation. In the culture treated with E5166, the cell cycle progression was markedly inhibited and an accumukation of the cells in G1/0 phase was apparent on day 4 when a small number of granulocyte first appeared. Subsequently, the percentage of differentiated cellsin the culture increased continuously with the time of treatment and on day 7, 80％ of cells acquired the morphological characteristics of mature granulocytes. The close relationship between cell kinetics and differentiation was suggested, although the mechanisms by which E5166 induces differentiation and exerts its antiproliferative effect on HL-60 are unknown.
- Yamaguchi University Graduate School of Medicineの論文
著者
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Okita Kiwamu
下関厚生病院(社保)
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Ohkawa Kazuyoshi
大阪大学
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Ogata Kei
The Second Department Of Medicine Division Of Kidney Disease And Critical Care Medicine Kurume Unive
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Okita Kiwamu
Department Of Gastroenterology And Hepatology Yamaguchi University Graduate School Of Medicine
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Okita K
Yamaguchi Univ. Yamaguchi Jpn
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Okita Kiwamu
First Department Of Internal Medical Yamaguchi University School Of Medicine
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MURAKAMI Tomoyuki
Second Department of Pathology, Yamaguchi University, School of Medicine
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Takahashi Manabu
Second Department Of Pathology Yamaguchi University School Of Medicine
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Orita Tetsuji
Department Of Neurosurgery Yamaguchi University School Of Medicine:department Of Neurosurgery Shuto
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Murakami Tomoyuki
Second Department Of Pathology Yamaguchi University School Of Medicine
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Sasaki Kohsuke
山口大学 病理
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