J024023 冷媒循環システムを利用した極細クライオプローブによる凍結領域制御([J02402]バイオにおける流れと熱・物質移動(2))

概要

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This paper describes a novel cryosurgical system in order to conduct cryosurgery for a small affected area. An ultrafine cryoprobe to generate a small frozen region and a refrigerant circulation system not to emit the refrigerant into atmosphere were used. This system consists of the ultrafine cryoprobe, the reservoir to store liquid refrigerant, the condenser to condense the refrigerant in vapor state and several valves. In the refrigerant recovery process, the condensed refrigerant was changed its state to room temperature by heating and returned to reservoir. HFC-23, which is alternative Freon, was used as refrigerant and the agar at 37°C was used as a cooling object to simulate a biological tissue. Moreover, this system was able to control the frozen region by using the bypass valve and its effectiveness was confirmed by the freezing experiment. In the freezing experiment, the temperature of cryoprobe surface reached at ?25°C and the frozen region of 2 mm in radius was generated in 20 seconds. Furthermore, the controllability of frozen region was also confirmed by changing the time to open bypass valve.
一般社団法人日本機械学会の論文
2011-09-11