An Important Role of Oxidative LDL in Progression of Hyperlipidemic Renal Disease Evidenced from LDL Apheresis(Workshop1-12)

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We report here that oxidized LDLs were found in patients with steroid-resistant nephrotic syndrome as well as in more advanced atherosclerotic disease. Of the patients in our study, four, aged 32 to 66 years old, were introduced to LDL apheresis. Two patients showed reduction in oxidized LDL following remission of severe proteinuria. However, the others, who did not show significant reduction in oxidative LDL, did not demonstrate any improvement in proteinuria. As LDLs were more oxidatively modified, they became more negatively charged and harder to remove with commercially available LDL absorbent. We suggest that it is important to aim at the reduction of not only LDL but also oxidized LDLs in the application of LDL apheresis therapy.
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