1C1-5 周期発現パターンをもつ遺伝子ネットワークの設計法 : ポアンカレ写像を用いた実現(機械学習)

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Recently, synthesis of gene regulatory networks having desired behavior has become of interest to many researchers and several studies have been done. There exist periodic phenomena in cells and those are considered to be generated by gene regulatory networks. In this paper, we discuss a synthesis problem of gene regulatory networks having desired cyclic expression pattern sequences. Gene regulatory networks with cyclic expression pattern sequences do not always exhibit periodic behavior. Therefore we have proposed a synthesis method of gene regulatory networks having desired expression pattern sequences with their corresponding solution trajectories being periodic by specifying passing points of them. However there does not always exist a gene regulatory network having a solution trajectory passing through these specified points. In this paper, we propose a synthesis method in which we introduce Poincare maps for desired cyclic expression pattern sequences and make it have a specified fixed point. There are many cases in which a passing point of a solution trajectory can be found by using a prior knowledge about objective gene regulatory networks.
一般社団法人日本機械学会の論文
2011-09-01