Effects of dissolved oxygen level on rapamycin production by pellet-form of Streptomyces hygroscopicus(BIOCHEMICAL ENGINEERING)

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概要

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• Rapamycin was known to have the functions of being an antibiotic and immunosuppressant; recently it was also recognized as being able to retard the aging process. The effects of dissolved oxygen (DO) level on rapamycin production by pellet-form of Streptomyces hygroscopicus were investigated in this study. The results suggest that a high DO level is required to enhance rapamycin production. However, the premise for getting a high rapamycin concentration by using DO control was keeping the intact of pellet-form of S. hygroscopicus. What if the high DO level achieved was coming from the increase of agitation; it might break down the morphology of pellets-form in the fermentation tank and result in the decrease of rapamycin production. The maximum rapamycin obtained in this study was about 780 mg/L in the 5 L fermentor batch with DO controlled over 30%, with the supplement of pure oxygen in the inlet gas, and the agitation speed limited to less than 200 rpm. Conclusively, a high DO level and the morphology of pellets form both were detrimental to achieving a high rapamycin production by S. hygroscopicus in the agitation fermentor.

• 公益社団法人日本生物工学会の論文

著者

• Yen Hong-wei

  Department Of Chemical And Materials Engineering Tunghai University

• Yen Hong-Wei

  Department of Chemical and Materials Engineering, Tunghai University

• Hsiao Hsin-Pei

  Department of Chemical and Materials Engineering, Tunghai University

関連論文

• Effects of dissolved oxygen level on cell growth and total lipid accumulation in the cultivation of Rhodotorula glutinis(BIOCHEMICAL ENGINEERING)
• Use of poly(ether-block-amide) in pervaporation coupling with a fermentor to enhance butanol production in the cultivation of Clostridium acetobutylicum(BIOCHEMICAL ENGINEERING)
• Using crude glycerol and thin stillage for the production of microbial lipids through the cultivation of Rhodotorula glutinis(BIOCHEMICAL ENGINEERING)
• Effects of dissolved oxygen level on rapamycin production by pellet-form of Streptomyces hygroscopicus(BIOCHEMICAL ENGINEERING)
• Using crude glycerol and thin stillage for the production of microbial lipids through the cultivation of Rhodotorula glutinis

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