RNA Overshoot Accompanies Recovery of Delayed Plantaris Muscle Growth Resulting from Juvenile Hindlimb Suspension

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概要

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• Delay in the growth of skeletal muscle resulting from physical inactivity during the juvenile period may affect the subsequent quality of life. Therefore, it is important to clarify whether recovery of this muscle growth delay can be achieved by physical training thereafter. In the present study, mice were subjected to hindlimb suspension from 5 to 8 weeks of age to induce a delay of muscle growth and reloading from 8 weeks of age to recovery of muscle. Growth of the plantaris muscle, which is composed of fast-twitch fibers, was monitored at 5, 8, 11 and 14 weeks of age. This revealed that the growth of the plantaris had completely recovered from this delay by 11 weeks of age. Moreover, the recovery was accompanied by a significant increase of RNA content relative to control muscle. Since ribosomal RNA accounts for the majority of total RNA, it was thought that the machinery for protein synthesis had become activated in the recovering muscle. In addition, phosphorylated ribosomal protein S6, which is an important factor for efficient translation, was increased at the same time. These results suggested that protein synthesis was enhanced in recovering muscle. In addition, the recovering muscle showed activation of the Erk pathway, one of the pathways controlling the expression of ribosomal RNA. These results suggest that loss of skeletal muscle due to unloading during the juvenile period can be completely recovered by reloading, and that this recovery might require an increase of RNA content mediated by the Erk pathway.

• 2013-07-00

著者

• MACHIDA Masanao

  Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Takemasa Tohru

  Physical Education Health And Sport Sciences Graduate School Of Comprehensive Human Sciences Univers

• Takeda Kohei

  Physical Education Health And Sport Sciences Graduate School Of Comprehensive Human Sciences Univers

• Kiyosawa Hidenori

  Department Of Cell Science Institute Of Biomedical Sciences Fukushima Medical University School Of M

• Machida Masanao

  Physical Education Health And Sport Sciences Graduate School Of Comprehensive Human Sciences Univers

• KIYOSAWA Hidenori

  Department of Environmental Medicine, Kochi Medical School, Kochi University

• MACHIDA Masanao

  Organization for General Education, Saga University

• FUJIMAKI Shin

  Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST)

• IKEMUNE Sachiko

  Course of Acupuncture and Moxibustion, Division of Health Sciences, Tsukuba University of Technology

• NESORI Sachie

  Hokota Second High School

• FUJIMAKI Shin

  Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST):Physical Education, Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• IKEMUNE Sachiko

  Course of Acupuncture and Moxibustion, Division of Health Sciences, Tsukuba University of Technology:Faculty of Health Care Department of Acupuncture and Moxibustion, Teikyo Heisei University

• MACHIDA Masanao

  Organization for General Education, Saga University:Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST):Physical Education, Health and Sport Sciences, Graduate School of Comprehensive Human Sc

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