Increased Macrophages Following Endurance Exercise Without Severe Injury Play a Role in Angiogenesis in Skeletal Muscle
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概要
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Endurance exercise training promotes angiogenesis in skeletal muscle. In order to elucidate the mechanisms of exercise-induced angiogenesis in skeletal muscle, many researchers have focused on gene expression in skeletal muscle during and after an exercise, and it is well understood that acute endurance exercise induces temporarily increasing VEGF mRNA in skeletal muscle and secreting VEGF from active muscle. Because of these results, exercise-induced VEGF expression from skeletal muscle has been believed to be an early step of exercise-induced skeletal muscle angiogenesis. Recently it was revealed that inflammatory cells including macrophage secreted pro-angiogenesis cytokine including VEGF, which had an ability to facilitate angiogenesis in vivo. However the relationship between exercise-induced skeletal muscle angiogenesis and these inflammatory cells is not revealed. Therefore we had hypothesized that exercise-induced angiogenesis in skeletal muscle is facilitated by inflammatory cells secreting VEGF. To explore this hypothesis, we subjected ICR mice (male, 8 week-old) to acute endurance exercise (90min, 20m/min, 10° incline), sacrificed these mice by cervical dislocation at pre-exercise, 6 hour, 1 day, 2 day and 3 day after exercise, and harvested both gastrocnemius and plantaris muscle as hind-limb muscle. And, we used immunohistochemical method and observed significant increase of macrophage in hind-limb muscle at 1 day after exercise compared with pre exercise. Subsequently we observed that increment of percentage of VEGF-secreting macrophage. These results suggest that migrating macrophages have a positive role in exercise-induced angiogenesis in skeletal muscle.
著者
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MACHIDA Masanao
Graduate School of Comprehensive Human Sciences, University of Tsukuba
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MACHIDA Masanao
Physical Education, Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, Univ
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TAKEMASA Tohru
Physical Education, Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, Univ
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Takemasa Tohru
Physical Education Health And Sport Sciences Graduate School Of Comprehensive Human Sciences Univers
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Takemasa Tohru
Physical Education Health And Sport Sciences Graduate School Of Comprehensive Human Sciences Univers
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Machida Masanao
Physical Education Health And Sport Sciences Graduate School Of Comprehensive Human Sciences Univers
関連論文
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