Characterization of Stimulator of Interferon Genes (STING) Expression in Human Epidermal Keratinocytes

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概要

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• The innate immune system is the first line of defense against microbial pathogens, and the production and secretion of interferons （IFNs） plays an important role of the innate response to viral infections. Recently stimulator of interferon genes（ STING） has been identified as an intracellular adaptor, which activates both NF-κB and interferon regulatory factor 3（ IRF3） transcription pathways to induce IFNs. We demonstrated that the STING expression is regu-lated by stimulation of various cytokines in human epidermal keratinocytes （HaCaT）. Especially, IFN-γ induced the STING mRNA expression in a dose-dependent manner. On the oth-er hand, polyinosinicpolycytidylic acid（ poly I:C）, which mimics viral infection, has no effect on the STING expression. STING promoter analysis showed that a gamma-activated se-quence（ GAS） located at －58 to －66 bp is essential for IFN-γ-regulated promoter activity. Moreover, electrophoretic mobility shift assay revealed that STAT1 binds to the GAS element on the STING promoter region, indicating that IFN-γ/JAK/STAT1 signaling is critical for the expression of STING in human epidermal keratinocytes.

• 弘前大学の論文
• 2013-00-00

著者

• Matsuzaki Yasushi

  Department of Dermatology, Hirosaki University Graduate School of Medicine

• Nakano Hajime

  Department of Dermatology, Hirosaki University Graduate School of Medicine

• Sawamura Daisuke

  Department Of Dermatology Hirosaki University Graduate School Of Medicine

• Matsuzaki Yasushi

  Department Of Dermatology Hirosaki University Graduate School Of Medicine

• Nakano Hajime

  Department Of Cardiovascular Medicine Ohmori Hospital Toho University School Of Medicine

• Nishikawa Yohei

  Department Of Dermatology Hirosaki University School Of Medicine

• Sawamura Daisuke

  Department of Dermatology, Hirosaki University Graduate School of Medicine

• Nishikawa Yohei

  Department of Dermatology, Hirosaki University Graduate School of Medicine

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