Asymmetry of Interhemispheric Inhibition from Active to Resting Primary Motor Cortex Induced by a Fine-motor Manipulation Task of Either Dominant or Non-dominant Hand

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概要

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• We examined the interhemispheric inhibition (IHI) induced from the active primary motor cortex (M1) to the resting M1 in 11 right-handed subjects during their performance of a sensorimotor task with their dominant right (Rt)- hand or their non-dominant left (Lt)- hand. Transcranial magnetic stimulation (TMS) was performed to produce motor evoked potentials (MEP) in the resting first dorsal interosseous (FDI). For the paired-TMS paradigm, when the tasks were performed with the dominant Rt-hand, the test stimulus (TS) was delivered to the ipsilateral Rt-M1 and the con- ditioning stimulus (CS) was delivered to the contralateral Lt-M1, and the opposite was true when they were performed with the non-dominant Lt-hand. The interstimulus interval was fixed at 10 ms. As a sensorimotor task, a fine-motor manipulation (FM) task (using chopsticks to pick up, transport, and release glass balls) was adopted. In addition, an isometric abduction (LA) task was also performed as a control task. These tasks were carried out separately with each hand. In the non-dominant Lt-hand conditions, the FM task induced markedly stronger IHI from the active to the resting M1 than was observed at rest and during the IA task. In contrast, there were no differences in IHI among the tasks in the dominant Rt-hand conditions. The present findings suggest that the increased IHI from the active to the resting M1 observed during the FM task in the non-dominant Lt-hand conditions was related to reductions in the activity of the ipsilateral intracortical inhibitory circuit, as was found in our previous study.

• 2013-05-00

著者

• Funase Kozo

  Human Motor Control Laboratory Graduate School Of Integrated Arts And Sciences Hiroshima University

• Uehara Kazumasa

  Human Motor Control Laboratory Graduate School Of Integrated Arts And Sciences Hiroshima University

• MORISHITA Takuya

  Human Motor Control Laboratory, Graduate School of Integrated Arts and Sciences, Hiroshima University:the Japan Society for the Promotion of Science

• KUBOTA Shinji

  Human Motor Control Laboratory, Department of Human Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University

関連論文

• Age-dependent Changes in Corticospinal Excitability in Humans
• 1-B-15 Laterality of interhemispheric inhibition from active to resting motor cortex during a fine-motor manipulation task(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima))
• Asymmetry of Interhemispheric Inhibition from Active to Resting Primary Motor Cortex Induced by a Fine-motor Manipulation Task of Either Dominant or Non-dominant Hand
• O-22 Modulation of reciprocal Ia inhibition between Ia inhibitory interneurons and corticospinal neurons(The Proceedings of the 20th Annual Meetings of Japan Society of Exercise and Sports Physiology July 28・29,(Tsukuba))
• O-20 Changes in interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task(The Proceedings of the 20th Annual Meetings of Japan Society of Exercise and Sports Physiology July 28・29,(Tsukuba))
• Asymmetry of Interhemispheric Inhibition from Active to Resting Primary Motor Cortex Induced by a Fine-motor Manipulation Task of Either Dominant or Non-dominant Hand
• Changes in the Ipsilateral Motor Cortex Excitability Induced by Different Frequencies of Afferent Inputs in Healthy Subjects : A TMS Study

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