Age-dependent Changes in Corticospinal Excitability in Humans
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概要
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Motor functions, such as controlling body sway during standing or regulating the speed of a tapping movement, naturally decline with aging. Due to the functional decline of the motor cortex, cerebrum, and basal ganglia brought about reductions in neurotransmitter release, motor control decreases with age. Although individuals' dependence on cognitive processes for motor control increases with age, their attention capacity and recognition resources decline. As a result, motor function declines with aging. In fact, transcranial magnetic stimulation (TMS) and H-reflex studies have demonstrated that age-related functional changes occur in the corticospinal tract. For example, TMS-induced motor evoked potential amplitudes were decreased, the cortical silent period was shortened, and short-latency intracortical inhibition was attenuated. In addition, the ratio of the maximum H-reflex to the maximum M-response and the slope of the H-reflex recovery curve also decrease with aging. Moreover, reciprocal inhibition and presynaptic inhibition are also altered. These results indicate that corticospinal excitability changes with aging. However, the results of corticospinal excitability studies were not always consistent. Therefore, further systematic studies are required.
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関連論文
- Age-dependent Changes in Corticospinal Excitability in Humans
- 1-B-15 Laterality of interhemispheric inhibition from active to resting motor cortex during a fine-motor manipulation task(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima))
- Asymmetry of Interhemispheric Inhibition from Active to Resting Primary Motor Cortex Induced by a Fine-motor Manipulation Task of Either Dominant or Non-dominant Hand
- O-22 Modulation of reciprocal Ia inhibition between Ia inhibitory interneurons and corticospinal neurons(The Proceedings of the 20th Annual Meetings of Japan Society of Exercise and Sports Physiology July 28・29,(Tsukuba))
- O-20 Changes in interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task(The Proceedings of the 20th Annual Meetings of Japan Society of Exercise and Sports Physiology July 28・29,(Tsukuba))
- Asymmetry of Interhemispheric Inhibition from Active to Resting Primary Motor Cortex Induced by a Fine-motor Manipulation Task of Either Dominant or Non-dominant Hand
- Changes in the Ipsilateral Motor Cortex Excitability Induced by Different Frequencies of Afferent Inputs in Healthy Subjects : A TMS Study