酸素吸入により血液希釈が起こる

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Background: Oxygen administration is beneficial for the patient with hypoxia and/or hypoxemia. The physiologic effects of supplemental oxygen on hemodynamics and autonomic nervous system (ANS) have been well examined in healthy subjects. Relationship among erythrocytes and oxygen has well understood, however the effect of oxygen on whole blood profile has not been described although oxygen influences the hemodynamics and ANS. We studied the effect of supplemental oxygen on blood profile in combination with hemodynamics and ANS using healthy subjects. Methods: Forty healthy volunteers were enrolled in this study. Supplemental oxygen was administered through nasal canula 3 liter/min. Hemodynamics, parasympathetic nervous activity (the power spectral of high frequency) and sympathetic nervous activity (low frequency/high frequency ratio) were measured. Red blood cell count (RBC), white blood cell count (WBC), hematocrit (Ht), hemoglobin (Hb), mean corpuscular volume (MCV) and venous blood gas analysis were determined before and after oxygen administration. Results: Heart rate and cardiac output significantly decreased through oxygen administration. The spectral power of HF was significantly increased after stop of oxygen administration compared to baseline. RBC, WBC, Ht, and Hb were significantly decreased after oxygen administration. Conclusions: The blood profile data showed the significant decrease in blood corpuscles by oxygen administration. Supplemental oxygen administration causes an acute hemodilution.
2013-02-20

酸素吸入により血液希釈が起こる

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