透析液配管のバイオフィルムに関する基礎的検討(保健科学部)
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It has been pointed out that bio-active substances such as Endotoxins can find their way into the dialysate plumbing system, central to dialysis treatment. For that reason, a wide range of measures have been undertaken regarding dialysate purification in order to ensure that water quality management does not pose a problem. In modern dialysis treatment, dialysate water quality has improved dramatically, thereby reducing the threat of long-term complications to patients, yet the preponderance of Endotoxin substances remain. In the present dialysis system, the foramen magnum diameter film is considered to be the mainstream method. In reverse filtration and back diffusion, however, dialysate pollutants flowing with the blood stream is confirmed to have potentially-serious dangers to patients. When polluted substances caused by Endotoxins are included in the vivo, and the presence of Endotoxins in the dialysate membranes, dialyzer materials and liquid medicines must at all times be avoided. Therefore, the pivotal task hinges on the aseptical maintenance of the dialysate line, and specifically how to grasp it accurately in order to prevent the propagation of bacterial substances. Also, this study found no constant correlation between Endotoxin value and clinical signs, the complications of Endotoxins origins have not been confirmed with respect to water quality management. Moreover, in recent years, micro-organisms in the Endotoxins with the exception of Gram-negative bacteria and the formation of bacterial elements in the biofilm have attracted public attention. To establish line management using the washing method, the washing time appropriate to the water treatment equipment and dialysate plumbing is of central importance in order to ensure water quality in dialysate purification. To ensure dialysate purification in order to achieve QOL improvement in the vital prognosis of patients in every dialysis facility, improving the awareness of clinical-based managing staff is indispensable both to water quality and line management.
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