Structure prediction with FAMS for proteins screened critically to autoimmune diseases based upon bioimformatics
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概要
- 論文の詳細を見る
Drug discovery for autoimmune diseases is recently recognized to be an important task. In this study, we try to perform structure prediction of proteins whose gene promoter regions were previous reported to be specifically methelysed or de-methylased commonly for three autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. FAMS were employed for this purpose and we can predict three dimensional structure with significantly small enough P-values. Most of them are suggested to be self immunology related proteins and will be important drug target candidates. We also found some proteins which form complex with each other. The possibility of a new drug target, i.e., suppression of protein complex formation is suggested.
- 一般社団法人電子情報通信学会の論文
- 2012-06-21
著者
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Iwadate Mitsuo
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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Taguchi Y-h.
Department Of Physics Chuo University
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UMEYAMA HIDEAKI
Department of Biological Sciences, Chuo University
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ISHIDA SHIGEHARU
Department of Physics, Chuo University
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IWADATE MITSUO
Department of Biological Sciences, Chuo University
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IWADATE MITSUO
Department of Biological Science, Chuo University
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