Search of miRNAs critical for medulloblastoma formation using MiRaGE method (ニューロコンピューティング)
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概要
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MiRaGE method estimates critical miRNAs based upon gene expression profile of their target genes. Expression profile of mRNA/miRNA is measured for tissues from neonatal and adult mice (6 days and 30 days after birth: P6 and P30, respectively), and medulloblastomas (2-3 months old: MB) with Agilent microarray is analyzed by MiRaGE method. Comparison between P30 and MB gives us the list of significantly up(down)regulated miRNAs whose target genes are down(up)regulated. The obtained list is biologically reasonable, possibly due to accuracy of Agilent microarray measurement, thus we conclude that MiRaGE method is useful to investigate tissue formation processes, too.
- 2011-06-16
著者
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Taguchi Y-h.
Department Of Physics Chuo University
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Yasuda Jun
School Of Medicine Tohoku University:presently With Department Of Cellbiology The Jfcr Cancer Instit
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