Effect of melamine on GABAergic synaptic activity in infant rat hippocampal slices

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概要

• 論文の詳細を見る

• The scandal of melamine-contamination has not ended yet, the toxification of melamine continues to raise concerns for public health. It has been well known that fetus and infant periods play the most important role in brain development, then what effect on earth of melamine in children's center nervous system? In the present study, we investigated the effects of melamine (5×10^<-5>g/ml) on GABAergic synaptic activity, which reflecting the basal neurotransmission, in infant rat hippocampal CA1 neurons. The results showed that melamine significantly decreased the amplitude of miniature IPSCs (mIPSCs) without altering spontaneous IPSCs (sIPSCs), illustrating a postsynaptic mechanism of melamine actions on GABAergic synaptic transmission. These results suggested that melamine could alter GABAergic synaptic activity in infant rats, and further damaged the function of learning and memory.

• 日本脳科学会の論文
• 2012-10-30

著者

• Yao Yang

  Department Of Medical Oncology Sixth People's Hospital Shanghai Jiaotong University

• Guo Jie

  Department Of Biochemistry Dali University

• Guo Jie

  Department of Neurology, Tianjin First Center Hospital

• Yao Yang

  Department of Neurology, Tianjin First Center Hospital

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