BAL Fluid Concentrations of Cytokines in Patients with Nonspecific Interstitial Pneumonia, Usual Interstitial Pneumonia, Collagen Vascular Disease Associated with Interstitial Pneumonia, and Sarcoidosis

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概要

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• Background:Inflammatory cytokines have been reported to play important roles in the pathogenesis ofinterstitial lung diseases. However, their individual roles in idiopathic interstitial pneumonitis (IIP) and inthe other types of interstitial pneumonitis (IP), including collagen vascular disease associated interstitialpneumonitis (CVD-IP), remain unknown. In this study, we measured the bronchoalveolar lavage (BAL)fluid levels of several cytokines in patients with IIP and CVD-IP.Methods:Cell subpopulations in BAL fluid were counted, and BAL fluid levels of interleukin( IL)-2, -6,-7, -8, -17, interferon (IFN)-g , tumor necrosis factor (TNF)-a , and transforming growth factor (TGF)-b 1 were measured using a bead suspension array or an enzyme-linked immunosorbent assay( ELISA) kitin 16 patients (8 men, 8 women;mean age, 60.0±9.9 years) with idiopathic nonspecific interstitial pneumonitis(NSIP), 5 patients (3 men, 2 women;mean age, 69.0±4.8 years) with idiopathic usual interstitialpneumonitis (UIP), 5 patients (3 men, 2 woman;mean age, 66.3±5.5 years) with rheumatoid arthritis inCVD-IP (RA), and 5 patients (3 man, 2 women;mean age, 52.3±14.5 years) with dermatomyositis inCVD-IP( DM), and 13 patients( 3 men, 10 women;mean age, 51.8±17.2 years) with sarcoidosis.Results:BAL cell subpopulations had high amounts of lymphocytes in NSIP and sarcoidosis, and neutrophilsin RA. Levels of IL-7 were significantly (P<0.05) higher in DM (9.2±2.2 pg/ml) than in RA (4.5±1.7 pg/ml). IL-7 in DM was significantly( P<0.05) correlated with lymphocytes. The levels of TNF-a werehighest for RA( 18.6±29.5 pg/ml), compared with other IPs( 1.6±0.7 pg/ml in UIP, 1.8±2.7 pg/ml in NSIP,4.4±4.5 pg/ml in DM), and sarcoidosis( 5.8±6.1 pg/ml). In addition, the levels of IL-17 were highly detectablein RA( 2.5±2.5 pg/ml), but not in NSIP, UIP, or sarcoidosis.Conclusions:Differences in the cell types of BAL fluid and the level of each cytokine between patientswith IIP and CVD-IP might reflect pathogenesis and be useful for diagnosis.

• 2012-10-25

著者

• Kumiya Sugiyama

  Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University

• Takeshi Fukuda

  Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University

• Kumiya Sugiyama

  Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University Japan

• Fumiya Fukushima

  Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University Japan

• Masamitsu Tatewaki

  Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University Japan

• Hirokuni Hirata

  Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University Japan

• Yasutsugu Fukushima

  Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University Japan

• Sugiyama Kumiya

  スギヤマ,クミヤ

• Fukushima Fumiya

  フクシマ,フミヤ

• Hirata Hiroyuki

  ヒラタ,ヒロユキ

• Tatewaki Masamitsu

  タテワキ,マサミツ

• Fukushima Yasutsugu

  フクシマ,ヤスツグ

• Fukuda Takeshi

  フクダ,タケシ

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• Effect of Oral Procaterol in Combination with Inhaled Corticosteroids in Adult Patients with Bronchial Asthma
• BAL Fluid Concentrations of Cytokines in Patients with Nonspecific Interstitial Pneumonia, Usual Interstitial Pneumonia, Collagen Vascular Disease Associated with Interstitial Pneumonia, and Sarcoidosis

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