Role of Topological Exclusion in Formation and Organization of Chromosomal Territories(Statistical Physics and Topology of Polymers with Ramifications to Structure and Function of DNA and Proteins)

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概要

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• Chromosomes of eukaryotic organisms are composed of chromatin loops. Using Monte Carlo simulations we investigate how the topological exclusion between loops belonging to different chromosomes affects chromosome behaviour. We show that in a confined space the topological exclusion limiting catenation between loops belonging to different chromosomes entropically drives the formation of chromosomal territories. The same topological exclusion in a connection with interchromosomal binding via transcription factories explains why actively transcribed genes are found preferentially at the peripheries of their chromosomal territories. This paper is based in part on the results presented in J. Dorier and A. Stasiak, Nucl. Acids Res. 37 (2009), 6316 and 38 (2010), 7410.

• 2011-12-16

著者

• Stasiak Andrzej

  Center For Integrative Genomics Faculty Of Biology And Medicine University Of Lausanne

• Dorier Julien

  Center For Integrative Genomics Faculty Of Biology And Medicine University Of Lausanne

• DORIER Julien

  Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne

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• Cumulative Shapes of Knotted Polymers(Statistical Physics and Topology of Polymers with Ramifications to Structure and Function of DNA and Proteins)
• Role of Topological Exclusion in Formation and Organization of Chromosomal Territories(Statistical Physics and Topology of Polymers with Ramifications to Structure and Function of DNA and Proteins)

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