Inhibitory effect of DNA supercoiling on DNA knotting (結び目とソフトマター物理学--高分子のトポロジー、そして物理学、数学および生物学における関連する話題)

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概要

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• Using numerical simulations we investigated the effect of DNA supercoiling on the topological equilibrium of DNA molecules. We showed that under the steady state conditions that maintain the same effective deficit of the linking number in unknotted and knotted DNA molecules the topological equilibrium results in a much smaller fraction of knots than in the case of torsionally relaxed DNA molecules. Based on these results we propose that one of the important functions of DNA supercoiling is to reduce formation of DNA knots.

• 物性研究刊行会の論文
• 2009-04-20

著者

• Dorier Julien

  Center For Integrative Genomics University Of Lausanne

• Burnier Yannis

  Department of Physics, University of Bielefeld

• Stasiak Andrzej

  Center for Integrative Genomics, University of Lausanne

• Burnier Yannis

  Department Of Physics University Of Bielefeld

• Stasiak Andrzej

  Center For Integrative Genomics University Of Lausanne

• Stasiak Andrzej

  Center For Integrative Genomics Faculty Of Biology And Medicine University Of Lausanne

• Dorier Julien

  Center For Integrative Genomics Faculty Of Biology And Medicine University Of Lausanne

関連論文

• Inhibitory effect of DNA supercoiling on DNA knotting (結び目とソフトマター物理学--高分子のトポロジー、そして物理学、数学および生物学における関連する話題)
• Cumulative Shapes of Knotted Polymers(Statistical Physics and Topology of Polymers with Ramifications to Structure and Function of DNA and Proteins)
• Role of Topological Exclusion in Formation and Organization of Chromosomal Territories(Statistical Physics and Topology of Polymers with Ramifications to Structure and Function of DNA and Proteins)

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