2A2-G20 軟骨再生用HD MACs形成ロボットの開発

概要

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We've been working for developing scaffold free cell delivery system, and show good regeneration of rabbit osteochondral defect until more than three years by implantation of molded mesenchymal stem cells (MSC) construct without use of exogenous factors. The entire procedure is simple, yet, it takes time and labor to build a single construct by even experienced hands. Therefore, this study was aimed to develop a scaffold free HD MACs (High-density mesenchymal stem cell autologous constructs) building robot for cartilage regeneration, and evaluated the efficacy of the entire systems. In result, the scaffold free HD MACs could be obtained as same as manual procedure without contamination. We also implanted the construct into rabbit osteochondral defect in the knee.
一般社団法人日本機械学会の論文