担子菌培養抽出物であるAHCCのマウス四塩化炭素肝障害モデルに対する肝保護作用

概要

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Active Hexose Correlated Compounds (AHCC) extracted from cultured broth of Basidiomycotina were examined for their protective effects on carbon tetrachloride (CCl_4) -induced liver injury in mice. The AHCC treatment obviously suppressed the changes of several physiological and biochemical parameters in the mice injected with CCl_4 for 5 days: the decrease of body weights and the increases of liver weights, the sGPT (serum glutamate pyruvate transaminase) level and the level of LPO (lipid peroxide) induced by CCl_4 were significantly reduced by the AHCC treatment. The AHCC treatment also induced detoxication enzymes-GST (glutathione Stransferase) and UDP-GT (uridine diphosphate glucuronyl transferase) activities. AHCC also showed some effects on the CCl_4-induced suppressin of phase I drug-metabolizing enzymes. The anti-oxidant effect and the activity modifying-effect on drug-metabolizing enzymes might be related to the AHCC protection of liver from CCl_4-induced liver injury.
日本生薬学会の論文
1997-08-20