ダイオウ新鮮根とその乾燥品中のSennoside A, B含量の比較

概要

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Sennoside A (SA) and sennoside B (SB) contents in the roots of Rheum palmatum (RP) and R. coreanum (RC) were determined by HPLC. The combined SA and SB contents in hot water extracts were 0.24% and 0.28% in frozen fresh roots of RP and RC, respectively, whereas they were 1.07% and 1.42% in 60℃-dried roots of RP and RC, respectively. The contents in the dried roots were almost equivalent to those in the respective fresh materials when their weight losses on drying were taken into consideration. The SA-SB contents in acetonitrile-pyridine extracts of frozen roots were about 0.25% and 0.27% in RP and RC, respectively. Pretreatment with N, N-dimethyl-p-nitro-soaniline (DMNA) had no effect. TLC analysis of the above extraction mixtures showed that only a small or a very small amount of 8-glucosylrhein anthrone (8GRA) was present in the raw materials. These results indicate that SA and SB are the genuine constituents of raw rhubarb roots, and not the products of post-harvest transformation of 8GRA as in the case of the sennosides in senna leaves. Differences between senna leaves and the rhubarb roots in these respects are briefly discussed.
日本生薬学会の論文
1994-03-20