Aging and circadian rhythms
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概要
- 論文の詳細を見る
In many animal species including humans, numerous processes exhibit 24-hour (h) rhythms. The circadian clock regulates daily rhythms of behavior and physiology such as the sleep-wake cycle (activity/rest), autonomic nervous function, and neuroendocrine function. The mammalian master clock located in the suprachiasmatic nuclei (SCN) of the hypothalamus incorporates environmental information and orchestrates peripheral clocks in other tissues and organs. Various characteristics of daily rhythms undergo age-dependent changes with respect to amplitude, entrained phase, free-running period (τ), and reentrainability. The mechanisms underlying aging of the circadian clock have not been fully understood. This review discusses current findings on age-related changes in daily rhythms of behavior and physiology. 「Age-related changes in amplitude of circadian rhythm」In rodent models, age-related declines in the amplitude of circadian rhythms have been found for a diverse range of physiological functions including the activity-rest cycle, body temperature rhythm, melatonin regulation and sex hormone secretion.
- 藍野大学の論文
著者
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Hida Akiko
Department Of Human Genetics Graduate School Of Medicine University Of Tokyo
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Okawa Masako
Department Of Phychophysiology National Institute Of Mental Health National Center Of Neurology And
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Mishima Kazuo
Department Of Neuropsychiatry Akita Univ. School Of Medicine
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Okawa Masako
Department Of Sleep Medicine Shiga University Of Medical Science
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Mishima Kazuo
Department Of Psychophysiology National Institute Of Mental Health National Center Of Neurology And
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Hida Akiko
Department Of Psychophysiology National Institute Of Mental Health National Center Of Neurology And
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MISHIMA Kazuo
Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry
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HIDA Akiko
Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry
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