Effects of probiotic fermentation on the enhancement of biological and pharmacological activities of Codonopsis lanceolata extracted by high pressure treatment(METHODS)

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概要

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• This study was designed to evaluate the enhancement of antioxidant, antimicrobial, enzymatic, cytotoxic, and cognitive activities of Codonopsis lanceolata extracted by high pressure treatment followed by probiotic fermentation. Dried C. lanceolata samples were subjected to 400MPa for 20min and then fermented with Bifidobacterium longum B6 (HPE-BLF) and Lactobacillus rhamnosus (HPE-LRF) at 37℃ for 7 days. Compared to conventional extraction (CE-NF, 6.69mg GAE/g), the phenol amounts of HPE-BLF and HPE-LRF were significantly increased to more than 8mg GAE/g, while the lowest flavonoid contents were observed for HPE-BLF (0.44mg RE/mL) and HPE-LRF (0.45mg RE/mL) (p<0.05). Cinnamic acid was the most abundant phenolic acid in the fermented C. lanceolata. The highest DPPH scavenging activities were observed for HPE-BLF and HPE-LRF, with minimum EC_<50> values of 1.26 and 1.18mg/mL, respectively. The HPE-BLF and HPE-LRF samples exhibited the most noticeable antimicrobial activities against Staphylococcus aureus, Listeria monocytogenes, Salmonella Typhimurium, and Shigella boydii (MICs<15mg/mL). The fermented C. lanceolata samples effectively inhibited α-glucosidase and tyrosinase activities and potentially improved a scopolamine-induced memory deficit in mice. The application of a fermentation process can effectively improve the biological and pharmacological activities of high-pressure-extracted C. lanceolata by increasing the extraction efficacy and inducing probiotic conversion. The results suggest that the combined treatment of HPE and a fermentation process could be used as alternative extraction method over CE.

著者

• Park Sung-jin

  Department Of Orthopaedic Surgery Catholic University Of Korea College Of Medicine

• Ahn Juhee

  Division Of Bio Engineering College Of Bioscience And Biotechnology Kangwon National University

• Park Sung-jin

  Department Of Tourism Food Service Cuisine Hallym College

• He Xinlong

  Division of Biomaterials Engineering, Kangwon National University

• Zou Yunyun

  Division of Biomaterials Engineering, Kangwon National University

• Yoon Won-Byong

  Division of Food Science and Biotechnology, Kangwon National University

• Park Dong-Sik

  Division of Functional Food and Nutrition, Rural Development Administration

• Zou Yunyun

  Division Of Biomaterials Engineering Kangwon National University

• He Xinlong

  Division Of Biomaterials Engineering Kangwon National University

• Park Dong-sik

  Division Of Functional Food And Nutrition Rural Development Administration

• Yoon Won-byong

  Division Of Food Science And Biotechnology Kangwon National University

• Ahn Juhee

  Division Of Biomaterials Engineering Kangwon National University:research Institute Of Bioscience An

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