S0201-3-4 AFMによる細胞剛性同定に関する検討(骨再生と骨再建のためのバイオマテリアル(3),社会変革を技術で廻す機械工学)

概要

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Elastic modulus of cell is supposed to be an important parameter to monitor the activity of cell and the local variation of stiffness within cell may have some relation to the dynamics and force transfer of cell. Thus, it is desirable to obtain the local distribution of stiffness. An atomic force microscope(AFM) is used to measure the local mechanical properties of the cell and the experimental data obtained by the force curve mode are analyzed with a Hertz model. However, several theoretical assumptions that the Hertz model based on do no realized in the fore curve experiment on the cell. The objective of our study is to improve the Hertz model to obtain the elastic modulus of the cells. Relevant problems are also discussed in the present report.
一般社団法人日本機械学会の論文
2010-09-04