HIV撲滅の為の待ち伏せワクチン開発の基礎理論(一般講演-感性・記憶・知的システム-)

概要

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Teeming variable surface antigens of HIVs are induced by errorprone reverse transcriptase. Misreading, double reading, jumping reading, and frame shift reading are the essential mechanisms of antigen diversities. To predict these antigens, a cDNA coding transmembrane protein was sequenced by using universal PCR primers, analyzed and dispersed onto a evolutional time axis plate (EVTAP) using Fuzzy Logic. This EVTAP told us the future pathogenic amino acid peptide antigens to be conjugated to high molecular weight human serum proteins or HIV surface proteins for vaccination. If these predicted peptide antigens would be used prior to other anti HIV agents-treatment, mutant capture vaccine as this might exterminate HIVs to minimum levels in a patient and a healthy vaccine recipient would be protected by most types of HIV infections.
バイオメディカル・ファジィ・システム学会の論文
1997-10-16