S101 永久磁石を用いた静磁場刺激による骨誘導(力学適応能,自己組織化能を有するバイオマテリアル-生体インターフェイスの創製,SP1:シンポジウム1)

概要

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This study examined effects of the static magnetic field given by the magnetic assemblies (Hicorex Slim 4013, Hitachi Metals, Japan) on osteogenesis in vivo. They were implanted to 2 by 2 in both tibiae of male Japanese rabbits for 1, 2, 4, 8 and 12 weeks (n=6), and their osteogenesis was histologically observed. Osteoblast-like SaOS-2 cells suspended on the magnetic assemblies were regularly cultured. The static magnetic field seemed to stimulate and accelerate the osteogenesis within the early stage of its exposure. In addition, it also significantly (p<0.05) increased the cell proliferation and extracellular matrix (ECM) production of SaOS-2 cells both in 4 and 8 days' culture, and in fact, it accelerated or maintained the osteogenic differentiation of SaOS-2 osteoblasts.
社団法人日本機械学会の論文
2009-01-22